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Chemo-Induced Peripheral Neuropathy

Approximately 30-50% of patients undergoing chemotherapy for breast, colon, lung, and prostate cancers experience chemo-induced peripheral neuropathy (CIPN), which can develop during treatment and persist for weeks to months afterward (Memorial Sloan Kettering Cancer Center, 2022; Dana-Farber, 2023). The impact of CIPN varies based on factors such as chemotherapy type, dosage, frequency, and existing health conditions like diabetes or autoimmune diseases (Dana-Farber, 2023).

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CIPN can lead to weakness, numbness, and pain in the hands and feet, affecting how one functions in their everyday life along with impacting their quality of life (Mayo Clinic, 2023). While some symptoms of CIPN might improve with time, others can become permanent (Memorial Sloan Kettering Cancer Center, 2022).

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The video below provides a more in depth overview of what CIPN is.

Tips for CIPN management, comfort, and safety

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Understanding that CIPN can have a big impact on how one lives their life, below are some suggestions on how to reduce discomfort & improve function for your hands & feet as well as how to reduce your fall risk at home.

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Hands: reducing discomfort & improving function

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  • Use oven mitts & potholders in the kitchen to avoid burns

  • Wear gloves when performing gardening & yard work as well as in cold weather to keep your hands warm, even if they don't feel cold

  • Choose tools with large, nonslip handles that are easier to hold & use

    • You can buy adaptive foam or rubber grips to build up the handles of these tools or even use a washcloth and duct tape ​to DIY your own "built-up" grip

  • Consider using adaptive utensils and gadgets for eating & food preparation i.e. rocker knives and/or a vegetable chopper machine

  • Try non-skid liners/mats on counters/tables to steady plates & bowls when cooking/eating along with opening jars

  • Avoid lifting and carrying heavy objects, try to opt for smaller items to handle & transport.

    • For grocery shopping, consider either ordering your food online & having it delivered to your house or bringing a "granny-kart" to carry your items on wheels vs. carrying heavy bags​

  • Use electric appliances vs. manual appliances whenever possible

  • Use assistive technology and/or assistive settings for texting, typing, or communicating with others

  • Stay away from tight clothes & jewelry

  • Wear loose clothes and avoid buttons, or consider using velcro style button aids and/or magnetic buttons to make donning/doffing clothes easier

  • Try assistive devices like zipper pulls, button hooks, dressing sticks, reachers, sock aids, and shoe horns to make dressing easier

  • Consider elastic shoe laces, velcro straps, or slip on shoes to minimize the fine motor movement to tie your shoes

  • Try a blow dryer stand to minimize needing to hold your blow dryer

  • Use a thermometer to check the temperature of water before handling it to avoid burning yourself or freezing yourself

    • If you don't have a thermometer, try using another part of your body that is not affected by the neuropathy to test the temperature of water prior to using it​

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Feet: reducing discomfort & improving function

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  • Avoid going barefoot or wearing open-toed shoes to prevent foot injuries

  • Invest in orthopedic shoes and socks to increase mobility, reduce pain and offer better balance and support

    • Consider trying "rocker bottom" shoe soles and/or soft shoe inserts​

    • Make sure there is a comfortable amount space in your shoes for your feet i.e. extra width & deep toe boxes at the front of your shoe

    • Keep your shoes updated and strive to use the ones with the best support often i.e. tennis shoes or running sneakers

    • If unsure where to start, consult a foot specialist to get fit to find the best shoe for you

  • Attach a bell to your shoe laces to increase your awareness of foot placement when you are walking around

  • Use anti-fatigue mats in the kitchen, bathroom, or other frequently used areas of the home to relieve pressure/pain from your feet

  • Consider using a high stool or chair in busy parts of your house for sitting breaks to provide relief to your feet while doing chores, grooming, or working in the kitchen​

  • Wear socks in the winter to keep your feet warm, even if they don't feel cold

  • Try compression stockings to provide equal pressure to support your feet to provide relief from the pain & discomfort of peripheral neuropathy.

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Home: reducing risk for falls

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  • Use a cane, walker, electric scooter, or wheelchair (depending on your level of mobility) to help maintain your balance and/or to provide extra support when getting around in your home & in the community

    • For assistive devices such as walkers, wheelchairs, and/or electric scooters, consider attaching a basket to help with carrying personal items around the house or in the community​

  • Consider foot braces to help alleviate pain caused by nerve compression, to prevent foot drop, and to support your balance

  • Adapt your bathroom with grab bars, non-slip bathmats, shower benches/chairs to provide extra support with transfers into & out the shower, bathtub, and on & off the toilet

  • Install handrails in areas with steps

  • Remove loose rugs or invest in adhesive/pinning accessories to help secure them in your home i.e. carpet tape, rug pads, rug pins, etc.

  • Strive to remove clutter from your house and yard to create clear walk-ways

  • Invest in keeping the rooms of your home well-lit, even at night.  Try placing night lights throughout the house to illuminate walkways when it is dark

  • Use on/off switches for lighting that don't require bending over i.e. clicker, fingertip touch, or motion sensor

References

Brown, T. J., Sedhom, R., & Gupta, A. (2019, February 28). Chemotherapy-Induced Peripheral Neuropathy. JAMA Oncology. https://jamanetwork.com/journals/jamaoncology/fullarticle/2726030​

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Campbell, N. (2022). Neuropathy: How strength and balance can help [PowerPoint slides]. IWMF, Zakim Center for Integrative Therapies and Healthy Living. https://iwmf.com/wp-content/uploads/2022/01/Nancy-Campbell-PN-Slides.pdf​

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Dana-Farber Cancer Institute. (2023). Tips for managing neuropathy. Dana-Farber Cancer Institute. https://www.dana-farber.org/health-library/articles/tips-for-managing-neuropathy/​

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Doctor Grew Explains Cancer. (2022, February 9). Doctor Explains Chemotherapy Induced Peripheral Neuropathy [Video]. YouTube. https://www.youtube.com/watch?v=k3GGyRXlZtY​

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Evans, J. (2022, October 25). Nerve desensitization techniques. ProTailored Physical Therapy. https://protailored.com/nerve-desensitization-techniques/​

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​Leverette, M. M. (2022, November 21). 11 ways to keep rugs from sliding. the spruce . https://www.thespruce.com/prevent-sliding-rugs-5115051

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Mayo Clinic Staff. (2023, July 8). Peripheral neuropathy. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/symptoms-causes/syc-20352061​

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Mayo Clinic Staff. (2022, April 28). Relaxation techniques: try these steps to reduce stress. Mayo Clinic. https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/relaxation-technique/art-20045368​

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Memorial Sloan Kettering Cancer Center. (2022, August 23). Answers to 8 FAQ about chemotherapy-induced peripheral neuropathy (CIPN). Memorial Sloan Kettering Cancer Center. https://www.mskcc.org/news/answers-faq-about-chemotherapy-induced-peripheral-neuropathy-cipn​

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Molassiotis, A., Cheng, H. L., Leung, K. T., Li, Y. C., Wong, K. H., Au, J. S., Sundar, R., Chan, A., Ng, T. R., Suen, L. K. P., Chan, C. W., Yorke, J., & Lopez, V. (2019). Risk factors for chemotherapy-induced peripheral neuropathy in patients receiving taxane- and platinum-based chemotherapy. Brain and Behavior, 9(6), e01312. https://doi.org/10.1002/brb3.1312​

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Nash, J. (2023, February 16). Guided imagery in therapy: 20 powerful scripts and techniques. PositivePsychology.com. https://positivepsychology.com/guided-imagery-scripts/​

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OncoLink Team. (2021, April 27). How can occupational therapy assist with chemotherapy-induced peripheral neuropathy?. OncoLink. https://blogs.oncolink.org/2021/04/how-can-occupational-therapy-assist-with-chemotherapy-induced-peripheral-neuropathy/​

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Riopel, L. (2019, November 28). 28 Best Meditation Techniques for Beginners to Learn. PositivePsychology.com. https://positivepsychology.com/meditation-techniques-beginners/​

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Selvy, M., Kerckhove, N., Pereira , B., Barreau, F., Nguyen, D., Busserolles, J., Giraudet, F., Cabrespine, A., Chaleteix, C., Soubrier, M., Bay, J.-O., Lemal, R., & Balayssac, D. (2021). Prevalence of chemotherapy-induced peripheral neuropathy in multiple myeloma patients and its impact on quality of life: a single center cross-sectional study. Frontiers in Pharmacology, 12, 637593. https://doi.org/10.3389/fphar.2021.637593

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STAR Oncology Program. (2016). Stanford Healthcare Tri-Valley Integrative Cancer Services CIPN Handout.

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Winsantor. (n.d.). Living safely with peripheral neuropathy. Winsantor. http://winsantor.com/living-safely-with-peripheral-neuropathy/#:~:text=Products%20such%20as%20foot%20braces,and%20numbness%20in%20your%20feet

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